Though I often use Zellij as terminal multiplexer when working on remote machine, sometimes I need to switch to byobu for its feature of keeping session alive when I disconnect SSH.
One inconvenience with byobu is that, when running Helix inside it, the "copy to clipboard" feature (press Space then y) stops working. Only recently did I learn that one of the backends that Helix uses for the clipboard feature is "tmux", the same software under byobu's hood. It means that, when running in byobu, Helix should still be able to do "copy to clipboard", it is just a configuration matter that byobu disable the feature.
Here is how to make the "copy" works again, open ~/.config/byobu/profile.tmux file and add these lines:
set -g set-clipboard on
set-option -g allow-passthrough on
Save it. Quit byobu then run it again. Open Helix, the Space + y keys should work.